Seizures are defined by abnormal synchronous electrical activity of populations of neurons.  Although behavioral and clinical features of seizure vary, their underlying trigger is always an escalating synchronization of neuronal activity that can begin prior to convulsive events.  Depending on its epicenter and nature, the manifestation of a seizure can range from subtle signs to severe convulsions.  EEG remains the gold standard for preclinical and clinical assessment of seizures. EEG studies can identify a liability early in development, allowing for fast decisions and cost savings. 

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Our analyses of preclinical acute EEG or telemetry/video-EEG follow established tenets for the assessment of neuropharmacologic effects and is aligned with the neurology clinical practice and ILAE (The International League Against Epilepsy) classifications for seizures, status epilepticus, and interictal discharges indicative of increased risk of seizure (spikes, sharp waves, abnormal slowing, etc.).  Our clinical EEG analyses involve direct and automated searches and expert neurologist data reads.