Nerve Conduction  and EMG in preclinical drug development

Non-invasive electrophysiological tests such as peripheral nerve conduction velocity measurements (NCV) and electromyography (EMG) measure peripheral neuromuscular dysfunction and are used to assess toxicity, neuroprotective properties of novel compounds, or as key endpoints in studies using animal models of disease (e.g. diabetes or chemotherapy models). 

NCV and EMG studies in animal models are clinically translatable and provide information comparable to evaluations of peripheral neuropathy in patients such as the presence of a neuropathy, the type of fibers affected (motor, sensory or both) and the type of pathophysiology (axonal loss vs. demyelination).

Tests can be performed in small and large animals and can be customized to the research purpose.  Testing can be performed at the client's site or through PCEC, either GLP or non-GLP.