NEUROANALYTICS EXPERTS
from preclinical discoveries to clinical applications
We are a cross disciplinary team of neurophysiologists and data analysts dedicated to translating the latest advances in neuroscience and neuroimaging research into impactful applications in drug development and personalized medicine.
THE PCEC DIFFERENCE
-
Scientific Excellence
As a dynamic consortium of expert consultant neurophysiologists, data scientists, and software engineers, we are dedicated to translating advances in neuroscience and neuroimaging into impactful applications for drug development and personalized medicine.
-
Data Management and Advanced Analytics
Comprehensive solutions that encompass data management, advanced computational analyses, and study or program interpretation ensuring that our partners can fully utilize biomarkers for maximal impact.
-
Laboratory Data Collection
Our seasoned preclinical electrophysiology laboratory scientists collect, curate, analyze, and interpret EEG data from rodents to large animals. We are fully integrated operationally to provide hands-on expertise at CROs in the US and Europe. We provide fast support when and where it is needed.
-
Proven Track Record
With a history of successful partnerships in the pharmaceutical development and clinical sectors, we have facilitated advances in drug development and neurotherapeutic approaches.
CNS
CENTRAL NERVOUS SYSTEM
DRUG SAFETY
-
EEG remains the gold standard for preclinical and clinical seizure or prodromal event detection indicative of a drug’s seizurogenic potential. Our team has decades of experience reading and interpreting EEG data from all research-relevant species.
-
Our industry-leading experts integrate with your project team to provide scientific, operational, and regulatory guidance in finding practical and cost-effective solutions when a convulsive risk is identified behaviorally.
-
Based on our deep expertise with both morphology-based and computational EEG approaches, we provide unique and sensitive solutions for evaluating a convulsive risk for drugs with CNS pharmacologic effects, or to address the release from a clinical hold.
PNS
PERIPHERAL NERVOUS SYSTEM
APPLICATIONS
-
Nerve conduction studies evaluate nerve integrity, while electromyography (EMG) helps in assessing muscle dysfunction. Together, these assays aid in evaluating treatment efficacy, optimizing dosages, and ensuring drug safety.
We are unsurpassed leaders in the development and execution of clinically translatable nerve conduction studies in all preclinical species from rodents to large animals.
-
We support your team in all decision-making related to preclinical neuropathy derisking. Our scientists have extensive field expertise, technical proficiency, and a proven track record in EMG and nerve conduction studies, across a wide spectrum of research applications.
-
Our scientists were instrumental to the success of many cutting-edge nerve regeneration studies, probing reinnervation and recovery using custom electrophysiology methodology.
-
Nerve conduction studies and EMG play pivotal roles in muscle disease research and development of targeted therapies.
EEG
ELECTROENCEPHALOGRAPHY
NEURO-ANALYTICS
-
Quantitative EEG (qEEG) is a valuable tool in both drug development and clinical settings, providing detailed analysis of brain activity that can inform treatment decisions and drug efficacy.
Drug Development: In pharmaceutical research, qEEG is used to evaluate the efficacy of new drugs on brain function, particularly for CNS active drugs targeting psychiatric and neurological disorders. ML approaches for qEEG biomarkers are becoming increasingly useful for developing drugs effective and safe therapies.
Clinical Applications: Clinically, qEEG supports the diagnosis and management of epilepsy. By providing a detailed map of brain activity, qEEG helps in localizing the areas of disturbance, assessing disease progression, and monitoring the brain's response to treatment. It is also particularly useful as a biomarker and for personalizing treatment plans, allowing clinicians to tailor interventions based on the specific brain activity patterns of patients.
-
By integrating qEEG with sleep analytics, researchers gain a wider understanding of the effects of drugs on both sleep architecture and the underlying brain activity. This approach enhances the translational relevance of preclinical findings.
-
In addition to morphology-based analytics, we employ qEEG to separate benign or desired pharmacologic effects from a true risk of seizure, to help define a more precise NOAEL.
a multivariate, multimodal, cross-species
EEG NeuroInformatics Workspace
-
Research
EEG in drug discovery
Advanced statistics / ML / AI
Mechanistic Insights
-
Preclinical
Drug Safety
Drug efficacy & PK/PD
Mutlivariate biomarkers
-
Clinical Trials
Target engagement
Advanced biomarkers
Normative EEG-neuroimaging
Reducing response heterogeneity
-
Clinical
Personalized medicine
Disease biomarkers
Neuromodulation
Connectonomics - Neurotransmitter Predictions - AI Ready
COLLECTIONS
ELECTROPHYSIOLOGY
Hands-on electrophysiology experts
-
We have developed and validated precise, rigorous, and reproducible collection methods for a wide range of preclinical models. Our team excels at adapting to the operational flow of any laboratory environment.
With our state of the art equipment and fast response, we travel to your facility of choice and ensure that you have access to high-quality electrophysiology data collection, when you need it.
We are unsurpassed leaders in the development and execution of clinically translatable nerve conduction studies in all preclinical species from rodents to large animals.
-
We provide support in designing EEG, ERP, and NCS studies for research, diagnostic, and neuromodulation applications.
when and where you need them
Our partners
Drug development teams
Clinical trial sites
Preclinical CROs
Defense / countermeasure projects
Neuromodulation clinics
Neurostimulation clinics
Academic labs
Neurologists, psychiatrists, psychologists, and clinicians using qEEG/t
Consumers interested in brain biometrics
Pharma Industry Consultant, NC
"We were able to strengthen our clinical efficacy dataset with qEEG biomarkers of network connectivity indicative of synaptic modulation, in the absence of drug effects on the spectral power. The group's computational capabilities are best in class in the drug development space."
Joseph Arezzo, Ph.D. Professor of Neuroscience and Neurology; Albert Einstein College of Medicine
"I am very impressed with both the quality of processing and the interpretation of preclinical EEG findings. I have great respect for the work that Dr. Metea has done – she is one of the most highly knowledgeable scientists in this field."
Lowry Curley, CEO, Senior Scientist, Pharma, CA
"First choice for preclinical nerve conduction. Appreciated the knowledge shared in support of a molecule with peripheral neuropathy liabilities requiring nerve conduction."
Lowry Curley, CEO, Axosim
"Dr. Monica Metea's expertise helped us develop and validate a novel in vitro MEA electrophysiological system with complex neurobiology. She helped us interpret some of our results, and added more robust analysis packages. Now we have further engaged her to design technology upgrades to automate our processes."
CSO, biotech company
"Nerve conduction studies were instrumental in developing a novel nerve graft. We appreciated PCEC's scientific and technical hands-on expertise in support of study design and their flexibility in working with the study site CRO and regulatory agencies."
Project Lead, Pharma, MA
"The quality of EEG analyses for seizure derisking and overall study coordination was outstanding. We were able to make fast decisions in defining safety margins and advance our program for a CNS-active small molecule."
L.M., neuromodulation patient
The neurofeedback protocol designed by Dr. Metea was a key step in my son's recovery from depression. We were treated like family throughout the whole process. Thank you!
Licensed Clinical Psychologist, Neurofeedback clinic, TX
"Fast and complete clinical qEEG reports and competitive pricing, with competent recommendations for brain training. I appreciated the availability of several clinical experts with neuromodulation background when I had questions. Thanks!"